Mechanisms and clinical implications of intervertebral disc calcification

U Zehra, M Tryfonidou, JC Iatridis… - Nature Reviews …, 2022 - nature.com
Low back pain is a leading cause of disability worldwide. Intervertebral disc (IVD)
degeneration is often associated with low back pain but is sometimes asymptomatic. IVD …

Cell-based strategies for IVD repair: clinical progress and translational obstacles

ALA Binch, JC Fitzgerald, EA Growney… - Nature Reviews …, 2021 - nature.com
Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Latest advances in cryogel technology for biomedical applications

A Memic, T Colombani, LJ Eggermont… - Advanced …, 2019 - Wiley Online Library
There exists a technological need for advanced materials with improved properties for
emerging biomedical applications. Recent developments in macroporous materials have …

[HTML][HTML] Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration

SM Richardson, G Kalamegam, PN Pushparaj, C Matta… - Methods, 2016 - Elsevier
Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

D Sakai, GBJ Andersson - Nature Reviews Rheumatology, 2015 - nature.com
Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain,
which accounts for disability worldwide. Despite the known outcomes of the IVD …

[HTML][HTML] TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair

Q Wei, D Liu, G Chu, Q Yu, Z Liu, J Li, Q Meng… - Bioactive Materials, 2023 - Elsevier
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability.
Endogenous repair strategies combining scaffolds and growth factors show great promise in …

Discogenic back pain: literature review of definition, diagnosis, and treatment

K Fujii, M Yamazaki, JD Kang… - Journal of Bone and …, 2019 - academic.oup.com
Discogenic back pain is multifactorial; hence, physicians often struggle to identify the
underlying source of the pain. As a result, discogenic back pain is often hard to treat—even …

Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations

TJ DiStefano, K Vaso, G Danias… - Advanced …, 2022 - Wiley Online Library
Emergent approaches in regenerative medicine look toward the use of extracellular vesicles
(EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration …

Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies

J Clouet, M Fusellier, A Camus, C Le Visage… - Advanced drug delivery …, 2019 - Elsevier
Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …

Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review

P Sampara, RR Banala, SK Vemuri, GR Av, S Gpv - Gene therapy, 2018 - nature.com
Intervertebral disc degeneration (IVDD) is a multi-factorial process characterized by
phenotypic and genotypic changes, which leads to low back pain and disability. Prolonged …