Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th
century. Since then, the availability of insulin has shifted the focus of diabetes treatment from …

Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes
exist. Our aim was to use a unique collection of pancreas samples recovered soon after …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Diabetes mellitus and related disorders significantly contribute to morbidity and mortality
worldwide. Despite the advances in the current therapeutic methods, further development of …

A major hypothesis for the etiology of type 1 diabetes (T1D) postulates initiation by viral
infection, leading to double-stranded RNA (dsRNA)-mediated interferon response and …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

This cumulative body of work shows clear evidence that β-cell stress, dysfunction, and death
are harbingers of impending T1D and likely contribute to progression of disease and insulin …

Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …