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Lipid droplets and the management of cellular stress
E Jarc, T Petan - The Yale journal of biology and medicine, 2019 - pmc.ncbi.nlm.nih.gov
Lipid droplets are cytosolic fat storage organelles present in most eukaryotic cells. Long
regarded merely as inert fat reservoirs, they are now emerging as major regulators of …
regarded merely as inert fat reservoirs, they are now emerging as major regulators of …
[HTML][HTML] Lipid droplets in cancer: guardians of fat in a stressful world
Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …
Their survival during severe nutrient and oxidative stress depends on their capacity to …
[HTML][HTML] Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …
and triglycerides. These molecules represent a highly efficient energy resource and can act …
Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis
Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …
Lipid droplets and cellular lipid metabolism
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …
The role of lipid droplets in metabolic disease in rodents and humans
Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the
last two decades there has been a dramatic growth in our understanding of LD biology and …
last two decades there has been a dramatic growth in our understanding of LD biology and …
High‐fat diets: modeling the metabolic disorders of human obesity in rodents
Abstract Research Methods and Procedures: High‐fat (HF) diet feeding can induce obesity
and metabolic disorders in rodents that resemble the human metabolic syndrome. However …
and metabolic disorders in rodents that resemble the human metabolic syndrome. However …
[HTML][HTML] Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Triacylglycerols (triglycerides)(TGs) are the major storage molecules of metabolic energy
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated …
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated …
Enzymes of triacylglycerol synthesis and their regulation
RA Coleman, DP Lee - Progress in lipid research, 2004 - Elsevier
Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions …
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions …
[HTML][HTML] The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlap** functions in adipocytes
Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …