Cellular functions of eukaryotic RNA helicases and their links to human diseases
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice
X Jiang, Y Cheng, Y Zhu, C Xu, Q Li, X **ng… - Nature …, 2023 - nature.com
In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …
discontinuous meiotic cell-cycle progression at both the transcriptional and post …
Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors
X Wang, J Zhu, H Wang, W Deng, S Jiao… - Nature …, 2023 - nature.com
The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …
enormous significance in the study of developmental biology and genetic breeding, despite …
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
Summary mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein
particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP …
particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP …
[HTML][HTML] Protein disulfide isomerase is essential for spermatogenesis in mice
Y Zhang, A Yang, Z Zhao, F Chen, X Yan, Y Han… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Spermatogenesis requires precise posttranslational control in the endoplasmic reticulum
(ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) …
(ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) …
Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
O Olotu, AR Koskenniemi, L Ma, V Paramonov… - Cell Reports, 2024 - cell.com
Cancer cells undergo major epigenetic alterations and transcriptomic changes, including
ectopic expression of tissue-and cell-type-specific genes. Here, we show that the germline …
ectopic expression of tissue-and cell-type-specific genes. Here, we show that the germline …
[HTML][HTML] Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set
D Ye, T Liu, Y Li, Y Wang, W Hu, Z Zhu… - Frontiers in …, 2023 - frontiersin.org
Image-based identification and quantification of different types of spermatogenic cells is of
great importance, not only for reproductive studies but also for genetic breeding. Here, we …
great importance, not only for reproductive studies but also for genetic breeding. Here, we …
DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1
Y Miao, T Zhang, M Guan, Q Zhao, R Zhang, X Liu… - MBio, 2024 - journals.asm.org
ABSTRACT DEAD-box helicase (DDX) family members play differential roles in regulating
innate antiviral immune response. However, the physiological roles played by DDX4 in …
innate antiviral immune response. However, the physiological roles played by DDX4 in …
Small non-coding RNAs in male reproduction
O Olotu, A Ahmedani, N Kotaja - Seminars in Reproductive …, 2023 - thieme-connect.com
Male reproductive functions are strictly regulated in order to maintain sperm production and
fertility. All processes are controlled by precise regulation of gene expression, which creates …
fertility. All processes are controlled by precise regulation of gene expression, which creates …