Cellular functions of eukaryotic RNA helicases and their links to human diseases

KE Bohnsack, S Yi, S Venus, E Jankowsky… - … reviews Molecular cell …, 2023 - nature.com
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles

D Overwijn, M Hondele - Trends in Biochemical Sciences, 2023 - cell.com
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice

X Jiang, Y Cheng, Y Zhu, C Xu, Q Li, X **ng… - Nature …, 2023 - nature.com
In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …

Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors

X Wang, J Zhu, H Wang, W Deng, S Jiao… - Nature …, 2023 - nature.com
The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

Y **e, S Gao, K Zhang, P Bhat, BP Clarke, K Batten… - Cell reports, 2023 - cell.com
Summary mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein
particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP …

[HTML][HTML] Protein disulfide isomerase is essential for spermatogenesis in mice

Y Zhang, A Yang, Z Zhao, F Chen, X Yan, Y Han… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Spermatogenesis requires precise posttranslational control in the endoplasmic reticulum
(ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) …

Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth

O Olotu, AR Koskenniemi, L Ma, V Paramonov… - Cell Reports, 2024 - cell.com
Cancer cells undergo major epigenetic alterations and transcriptomic changes, including
ectopic expression of tissue-and cell-type-specific genes. Here, we show that the germline …

[HTML][HTML] Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set

D Ye, T Liu, Y Li, Y Wang, W Hu, Z Zhu… - Frontiers in …, 2023 - frontiersin.org
Image-based identification and quantification of different types of spermatogenic cells is of
great importance, not only for reproductive studies but also for genetic breeding. Here, we …

DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1

Y Miao, T Zhang, M Guan, Q Zhao, R Zhang, X Liu… - MBio, 2024 - journals.asm.org
ABSTRACT DEAD-box helicase (DDX) family members play differential roles in regulating
innate antiviral immune response. However, the physiological roles played by DDX4 in …

Small non-coding RNAs in male reproduction

O Olotu, A Ahmedani, N Kotaja - Seminars in Reproductive …, 2023 - thieme-connect.com
Male reproductive functions are strictly regulated in order to maintain sperm production and
fertility. All processes are controlled by precise regulation of gene expression, which creates …