The mouse, as a model organism to study the brain, gives us unprecedented experimental
access to the mammalian cerebral cortex. By determining the cortex's cellular composition …

Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …

INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of
underlying causes. However, determining which model parameters agree with complex and …

Mechanistic models of single-neuron dynamics have been extensively studied in
computational neuroscience. However, identifying which models can quantitatively …

Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological,
molecular, and connectivity signatures. While considerable work has measured the average …

Correlated variability in cortical activity is ubiquitously quenched following stimulus onset, in
a stimulus-dependent manner. These modulations have been attributed to circuit dynamics …

Neurons in mouse primary visual cortex (V1) are selective for particular properties of visual
stimuli. Locomotion causes a change in cortical state that leaves their selectivity unchanged …

Trial-to-trial variability is a reflection of the circuitry and cellular physiology that make up a
neuronal network. A pervasive yet puzzling feature of cortical circuits is that despite their …

Cognitive function relies on a dynamic, context-sensitive balance between functional
integration and segregation in the brain. Previous work has proposed that this balance is …