Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Malnutrition in older adults has been recognised as a challenging health concern
associated with not only increased mortality and morbidity, but also with physical decline …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Sarcopenia is one of the main issues associated with the process of aging. Characterized by
muscle mass loss, it is triggered by several conditions, including sedentary habits and …

Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …