Saponins in cancer treatment: Current progress and future prospects

OO Elekofehinti, O Iwaloye, F Olawale, EO Ariyo - Pathophysiology, 2021 - mdpi.com
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

Natural products targeting tumour angiogenesis

X Lu, LJ Friedrich, T Efferth - British journal of pharmacology, 2023 - Wiley Online Library
Tumour angiogenesis is the formation of new blood vessels to support the growth of a
tumour. This process is critical for tumour progression and metastasis, making it an attractive …

Saponins as cytotoxic agents: An update (2010–2021). Part II—Triterpene saponins

I Podolak, K Grabowska, D Sobolewska… - Phytochemistry …, 2023 - Springer
Saponins make up an important group of natural glycosidic compounds which are
distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial …

Inhibiting angiogenesis by anti-cancer saponins: from phytochemistry to cellular signaling pathways

MB Majnooni, S Fakhri, SM Ghanadian, G Bahrami… - Metabolites, 2023 - mdpi.com
Saponins are one of the broadest classes of high-molecular-weight natural compounds,
consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing …

Angiogenesis-related functions of Wnt signaling in colorectal carcinogenesis

A Kasprzak - Cancers, 2020 - mdpi.com
Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Triterpenoids

RA Hill, JD Connolly - Natural Product Reports, 2020 - pubs.rsc.org
Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294–1329 This review covers
the isolation and structure determination of triterpenoids reported during 2015 including …

Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel

I Naz, S Ramchandani, MR Khan, MH Yang, KS Ahn - Molecules, 2020 - mdpi.com
Natural compounds extracted from plants have gained immense importance in the fight
against cancer cells due to their lesser toxicity and potential therapeutic effects. Raddeanin …

Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical …

S Fakhri, SZ Moradi, F Faraji, L Kooshki… - Cancer and Metastasis …, 2024 - Springer
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

[HTML][HTML] Anemone medicinal plants: ethnopharmacology, phytochemistry and biology

DC Hao, X Gu, P **ao - Acta pharmaceutica sinica B, 2017 - Elsevier
Abstract The Ranunculaceae genus Anemone (order Ranunculales), comprising more than
150 species, mostly herbs, has long been used in folk medicine and worldwide …

Recent advances in dietary androgen receptor inhibitors

L Ren, T Zhang, J Zhang - Medicinal Research Reviews, 2024 - Wiley Online Library
As a nuclear transcription factor, the androgen receptor (AR) plays a crucial role not only in
normal male sexual differentiation and growth of the prostate, but also in benign prostatic …