The role of lidocaine in cancer progression and patient survival
Since its development in 1943, lidocaine has been one of the most commonly used local
anesthesia agents for surgical procedures. Lidocaine alters neuronal signal transmission by …
anesthesia agents for surgical procedures. Lidocaine alters neuronal signal transmission by …
Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
Bacterial inhabitants of the body have the potential to play a role in various stages of cancer
initiation, progression, and treatment. These bacteria may be distal to the primary tumour …
initiation, progression, and treatment. These bacteria may be distal to the primary tumour …
G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer
Given the severe side effects of the treatments and poor survival, prognostic and predictive
biomarkers to guide management of pancreatic cancer are in critical need. We hypothesized …
biomarkers to guide management of pancreatic cancer are in critical need. We hypothesized …
Abundance of reactive oxygen species (ROS) is associated with tumor aggressiveness, immune response, and worse survival in breast cancer
Purpose Reactive oxygen species (ROS) are oxygen-containing molecules that have high
reactivity and play roles in protection or harm the cancer cells. We aimed to clarify the …
reactivity and play roles in protection or harm the cancer cells. We aimed to clarify the …
Elevated bile acid metabolism and microbiome are associated with suppressed cell proliferation and better survival in breast cancer
Bile acids are metabolized by the gut microbiome and are involved in fat absorption.
Contrary to their carcinogenic role in gastrointestinal cancers, bile acids have been reported …
Contrary to their carcinogenic role in gastrointestinal cancers, bile acids have been reported …
Enhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancer
Although the value of tumor-infiltrating lymphocytes is well known, the clinical relevance of
an increased immune response, specifically in breast cancer, has not been investigated …
an increased immune response, specifically in breast cancer, has not been investigated …
[HTML][HTML] Annexin A1 expression is associated with Epithelial–Mesenchymal Transition (EMT), cell proliferation, prognosis, and drug response in pancreatic cancer
Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein overexpressed
in pancreatic cancer (PC). ANXA1 expression has been shown to take part in a wide variety …
in pancreatic cancer (PC). ANXA1 expression has been shown to take part in a wide variety …
High Ki67 gene expression is associated with aggressive phenotype in hepatocellular carcinoma
Background Hepatocellular carcinoma (HCC) with high Ki67 protein expression, the most
commonly used cell proliferation marker, is associated with an aggressive biologic …
commonly used cell proliferation marker, is associated with an aggressive biologic …
Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival
Cancer-associated adipocytes are known to cause inflammation; however, the role of
adipogenesis, the formation of adipocytes, in breast cancer is unclear. We hypothesized that …
adipogenesis, the formation of adipocytes, in breast cancer is unclear. We hypothesized that …
MELK expression in breast cancer is associated with infiltration of immune cell and pathological compete response (pCR) after neoadjuvant chemotherapy
In experimental settings, maternal embryonic leucine zipper kinase (MELK), an apical
member of the snf1/AMPK serine-threonine kinases family, plays a role in tumor growth. We …
member of the snf1/AMPK serine-threonine kinases family, plays a role in tumor growth. We …