The genetic architecture of Parkinson's disease
Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …
common genetic variants contribute to disease risk, onset, and progression. Mutations in …
Parkinson disease and the immune system—associations, mechanisms and therapeutics
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
Genetics of Parkinson's disease: an introspection of its journey towards precision medicine
S Bandres-Ciga, M Diez-Fairen, JJ Kim… - Neurobiology of …, 2020 - Elsevier
ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
The genetics of Parkinson's disease and implications for clinical practice
JO Day, S Mullin - Genes, 2021 - mdpi.com
The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
Parkinson's disease: from pathogenesis to pharmacogenomics
R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
Identification of risk loci for Parkinson disease in Asians and comparison of risk between Asians and Europeans: a genome-wide association study
JN Foo, EGY Chew, SJ Chung, R Peng… - JAMA …, 2020 - jamanetwork.com
Importance Large-scale genome-wide association studies in the European population have
identified 90 risk variants associated with Parkinson disease (PD); however, there are …
identified 90 risk variants associated with Parkinson disease (PD); however, there are …
Parkinson's disease in the Western Pacific Region
Summary 1· 8 billion people of diverse ethnicities and cultures live in the Western Pacific
Region. The increasing longevity of populations in this region is a major contributor to the …
Region. The increasing longevity of populations in this region is a major contributor to the …
Dynamic control of the dopamine transporter in neurotransmission and homeostasis
M Bu, MJ Farrer, H Khoshbouei - NPJ Parkinson's disease, 2021 - nature.com
The dopamine transporter (DAT) transports extracellular dopamine into the intracellular
space contributing to the regulation of dopamine neurotransmission. A reduction of DAT …
space contributing to the regulation of dopamine neurotransmission. A reduction of DAT …
The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases
Background Interest in the interplay between host genetics and the gut microbiome in
complex human diseases is increasing, with prior evidence mainly being derived from …
complex human diseases is increasing, with prior evidence mainly being derived from …
Causal effects of blood lipids on amyotrophic lateral sclerosis: a Mendelian randomization study
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is
predicted to increase across the globe by~ 70% in the following decades. Understanding the …
predicted to increase across the globe by~ 70% in the following decades. Understanding the …