Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …
parenchymal injury, persistent activation of inflammatory response as well as sustained …
Targeting hepatic macrophages to treat liver diseases
F Tacke - Journal of hepatology, 2017 - Elsevier
Our view on liver macrophages in the context of health and disease has been reformed by
the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages …
the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages …
Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies
C Ju, F Tacke - Cellular & molecular immunology, 2016 - nature.com
Macrophages represent a major cell type of innate immunity and have emerged as a critical
player and therapeutic target in many chronic inflammatory diseases. Hepatic macrophages …
player and therapeutic target in many chronic inflammatory diseases. Hepatic macrophages …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
[HTML][HTML] Macrophage heterogeneity in liver injury and fibrosis
F Tacke, HW Zimmermann - Journal of hepatology, 2014 - Elsevier
Hepatic macrophages are central in the pathogenesis of chronic liver injury and have been
proposed as potential targets in combatting fibrosis. Recent experimental studies in animal …
proposed as potential targets in combatting fibrosis. Recent experimental studies in animal …
[PDF][PDF] Liver inflammation abrogates immunological tolerance induced by Kupffer cells
F Heymann, J Peusquens, I Ludwig‐Portugall… - …, 2015 - Wiley Online Library
The liver is essential for inducing immunological tolerance toward harmless antigens to
maintain immune system homeostasis. However, the precise cellular mechanisms of …
maintain immune system homeostasis. However, the precise cellular mechanisms of …
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
SL Friedman - Physiological reviews, 2008 - journals.physiology.org
The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …
[HTML][HTML] Hepatic inflammation and progressive liver fibrosis in chronic liver disease
AJ Czaja - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti-
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …
Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice
Background and Aims Obesity‐induced chronic inflammation is a key component in the
pathogenesis of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Increased …
pathogenesis of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Increased …
[HTML][HTML] Role of Kupffer cells in the pathogenesis of liver disease
Kupffer cells, the resident liver macrophages have long been considered as mostly
scavenger cells responsible for removing particulate material from the portal circulation …
scavenger cells responsible for removing particulate material from the portal circulation …