Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

The paired box transcription factor Pax7 was isolated by representational difference analysis
as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

In mammals, maintenance of energy and nutrient homeostasis during food deprivation is
accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues …

G proliferating cells maintain Pax7 but lose MyoD and withdraw from immediate
differentiation. These cells are typically located in clusters, together with Pax7 ve progeny …

Muscle satellite cells are believed to represent a committed stem cell population that is
responsible for the postnatal growth and regeneration of skeletal muscle. However, the …

The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each
cell type has a unique 3D genome organization that determines its cell identity. An …

Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle
growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite …