Neurodegenerative diseases are pathologies of the central and peripheral nervous systems
characterized by loss of brain functions and problems in movement which occur due to the …

The genetic landscape of neurodegenerative diseases encompasses genes affecting
multiple cellular pathways which exert effects in an array of neuronal and glial cell-types …

Gene therapy is an innovative approach in the field of regenerative medicine. This therapy
entails the transfer of genetic material into a patient's cells to treat diseases. In particular …

The polygenic and multifactorial nature of many psychiatric disorders has hampered
implementation of the personalized medicine approach in clinical practice. However …

Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset
neurodegenerative disease mainly affecting motor neurons. By screening chemical …

Huntington's disease (HD) is an inherited neurodegenerative disease characterized by
uncontrolled movements, emotional disturbances, and progressive cognitive impairment. It …

Ischemic cardiomyopathy, a leading cause of heart failure globally, arises from the
irreversible damage inflicted upon cardiac tissue following myocardial infarction. The limited …

N-acetylglucosamine kinase (NAGK) has been identified as an anchor protein that facilitates
neurodevelopment with its non-canonical structural role. Similarly, small nuclear …

As we near a complete catalog of mammalian cell types, the capability to engineer specific
cell types on demand would transform biomedical research and regenerative medicine …

The blood–brain barrier (BBB) is a component of the neurovascular unit formed by
specialized brain microvascular endothelial cells surrounded by astrocytes end-feet …