Humans have over 70 potassium channel genes, but only some of these have been linked
to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly
understood. We studied a family with hereditary persistent AF and identified the causative …

Benign familial neonatal convulsions (BFNC) is an autosomal dominant epilepsy of infancy,
with loci mapped to human chromosomes 20q13. 3 and 8q24. By positional cloning, a …

Background—Long-QT Syndrome (LQTS) is a cardiovascular disorder characterized by
prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden …

Potassium channels regulate electrical signaling and the ionic composition of biological
fluids. Mutations in the three known genes of the KCNQ branch of the K+ channel gene …

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …