The hnRNP family: insights into their role in health and disease

T Geuens, D Bouhy, V Timmerman - Human genetics, 2016 - Springer
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …

Tau interactome and RNA binding proteins in neurodegenerative diseases

T Kavanagh, A Halder, E Drummond - Molecular neurodegeneration, 2022 - Springer
Pathological tau aggregation is a primary neuropathological feature of many
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

A Bampton, LM Gittings, P Fratta, T Lashley… - Acta Neuropathologica, 2020 - Springer
Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …

hnRNP K is a haploinsufficient tumor suppressor that regulates proliferation and differentiation programs in hematologic malignancies

M Gallardo, HJ Lee, X Zhang, C Bueso-Ramos… - Cancer cell, 2015 - cell.com
Summary hnRNP K regulates cellular programs, and changes in its expression and
mutational status have been implicated in neoplastic malignancies. To directly examine its …

Heterogeneous nuclear ribonucleoproteins: implications in neurological diseases

YH Low, Y Asi, SC Foti, T Lashley - Molecular Neurobiology, 2021 - Springer
Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse
family of RNA binding proteins with multifarious roles. They are involved, directly or …

HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing

A Bampton, A Gatt, J Humphrey, S Cappelli… - Acta …, 2021 - Springer
Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously
expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid …

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant …

D Moujalled, A Grubman, K Acevedo… - Human Molecular …, 2017 - academic.oup.com
Abstract TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein
involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar …

Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes

M Montalbano, E Jaworski, S Garcia… - Frontiers in Molecular …, 2021 - frontiersin.org
Tau protein is a known contributor in several neurodegenerative diseases, including
Alzheimer's disease (AD) and frontotemporal dementia (FTD). It is well-established that tau …

Role of CD44high/CD133high HCT-116 cells in the tumorigenesis of colon cancer

JY Zhou, M Chen, L Ma, X Wang, YG Chen… - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
This study aimed to explore cell surface biomarkers related to cancer stem cells (CSCs) and
their role in the tumorigenesis of colon cancer. Various colon cancer cell lines were …