Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …

HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

In eukaryotes, the interaction of DNA with proteins and supramolecular complexes involved
in gene expression is controlled by the dynamic organization of chromatin inasmuch as it …

Angiogenesis is a complex biological process involving the coordinated modulation of many
genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the …

The increasing knowledge on the mechanisms responsible for hepatic fibrogenesis together
with the introduction of potentially more effective therapeutic strategies for chronic liver …

Excessive accumulation of extracellular matrix (ECM) in the kidneys and epithelial-to-
mesenchymal transition (EMT) of renal tubular epithelial cells contributes to the renal fibrosis …

Modulation of chromatin structure through histone acetylation/deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …