The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its
ease of growth in serum-free suspension culture and its amenability to transfection, this cell …

Vaccination is the most effective method to prevent influenza infection. However, current
influenza vaccines have several limitations. Relatively long production times, limited vaccine …

Host factors required for viral replication are ideal drug targets because they are less likely
than viral proteins to mutate under drug-mediated selective pressure. Although genome …

Annually, influenza virus infects millions of people worldwide. Vaccination programs against
seasonal influenza infections require the production of hundreds of million doses within a …

Influenza viruses cause annual seasonal epidemics and occasional pandemics of human
respiratory disease. Influenza virus infections represent a serious public health and …

One of the main challenges in the development of bioprocesses based on cell transient
expression is the commonly reported reduction of cell specific productivity at increasing cell …

Background Susceptibility to viral infections as well as their severity are higher in men than
in women. Heightened antiviral responses typical of women are effective for rapid virus …

Virus-like particles (VLPs) offer great promise as candidates for new vaccine strategies.
Large-scale approaches for the manufacturing of HIV-1 Gag VLPs have mainly focused on …

Vaccine manufacturing processes are designed to meet present and upcoming challenges
associated with a growing vaccine market and to include multi-use facilities offering a broad …

High cell densities in animal cell culture can be obtained by continuous perfusion of fresh
culture medium across hollow fiber membranes that retain the cells. Careful selection of the …