Inhibitors of histone deacetylases (HDACs) are nowadays part of the therapeutic arsenal
mainly against cancers, with four compounds approved by the Food and Drug …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post-translational modifications (PTMs). The …

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …

Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the
second most frequent malignant bone tumor. Due to its resistance to chemo-and …

Chondrosarcoma is a malignant tumor of bones, characterized by the production of cartilage
matrix. Due to lack of effective treatment for advanced disease, the clinical management of …

Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and
poor overall prognosis mainly in children and adolescents. Identifying the molecular …

It is now well recognized that mutations, deregulated expression, and aberrant recruitment of
epigenetic readers, writers, and erasers are fundamentally important processes in the onset …

Even though one is moving towards the success in the discovery of efficient anti-cancer
molecules, the drugs used in the treatment of various malignancies are found to possess …

Sarcomas represent an extensive group of divergent malignant diseases, with the only
common characteristic of being derived from mesenchymal cells. As such, sarcomas are by …

Histone modifying enzymes have vital roles in the growth and survival of both parasites and
humans. Targeting the epigenome can be a new strategy for the treatment of parasitic …