Pulmonary administration of drugs presents several advantages in the treatment of many
diseases. Considering local and systemic delivery, drug inhalation enables a rapid and …

Chitosan, as a biodegradable and biocompatible polymer, is characterized by anti-microbial
and anti-cancer properties. It lately has received a widespread interest for use as the …

Nanosizing of pharmaceutical drug particles is one of the most important drug delivery
platforms approaches for the commercial development of poorly water-soluble drug …

The delivery efficiency of dry-powder products for inhalation is dependent upon the drug
formulation, the inhaler device, and the inhalation technique. Dry powder formulations are …

The rise of antimicrobial resistance has created an urgent need for the development of new
methods for antibiotics delivery to patients with pulmonary infections in order to mainly …

Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …

Purpose Inhalation therapy is popular to treat lower respiratory tract infections. Azithromycin
is effective against some bacteria that cause respiratory tract infections; but it has poor water …

Highlights•Applications of alternative carriers to lactose in DPIs are reviewed.•Lactose, the
most commonly used carrier in DPI formulations, has some limitations.•These limitations …

The purpose of this study was to evaluate the effect of carrier particle size on properties of
dry powder and its effect on dry powder inhaler (DPI) performance. Commercial α-lactose …

Poly (ethylene glycol) based hydrogel microparticles were developed for pulmonary drug
delivery. Hydrogels are particularly attractive for pulmonary delivery because they can be …