Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR)
are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A …

Abstract Current US Food and Drug Administration-approved chimeric antigen receptor
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …

CD8+ T cells have a central role in antitumour immunity, but their activity is suppressed in
the tumour microenvironment,,,. Reactivating the cytotoxicity of CD8+ T cells is of great …

Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

AT cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ,
γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative …

TCR-pMHC interactions initiate adaptive immune responses, but the mechanism of how
such interactions under force induce T cell signaling is unclear. We show that force prolongs …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …