Solutions in microbiome engineering: prioritizing barriers to organism establishment
Microbiome engineering is increasingly being employed as a solution to challenges in
health, agriculture, and climate. Often manipulation involves inoculation of new microbes …
health, agriculture, and climate. Often manipulation involves inoculation of new microbes …
Sequencing-based analysis of microbiomes
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they
have varied functional roles that have an impact on agriculture, environmental sciences, and …
have varied functional roles that have an impact on agriculture, environmental sciences, and …
Nucleotide Transformer: building and evaluating robust foundation models for human genomics
The prediction of molecular phenotypes from DNA sequences remains a longstanding
challenge in genomics, often driven by limited annotated data and the inability to transfer …
challenge in genomics, often driven by limited annotated data and the inability to transfer …
Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4
Metagenomic assembly enables new organism discovery from microbial communities, but it
can only capture few abundant organisms from most metagenomes. Here we present …
can only capture few abundant organisms from most metagenomes. Here we present …
GTDB-Tk v2: memory friendly classification with the genome taxonomy database
Abstract Summary The Genome Taxonomy Database (GTDB) and associated taxonomic
classification toolkit (GTDB-Tk) have been widely adopted by the microbiology community …
classification toolkit (GTDB-Tk) have been widely adopted by the microbiology community …
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
IMG/VR v4: an expanded database of uncultivated virus genomes within a framework of extensive functional, taxonomic, and ecological metadata
Viruses are widely recognized as critical members of all microbiomes. Metagenomics
enables large-scale exploration of the global virosphere, progressively revealing the …
enables large-scale exploration of the global virosphere, progressively revealing the …
BUSCO: assessing genomic data quality and beyond
Abstract Evaluation of the quality of genomic “data products” such as genome assemblies or
gene sets is of critical importance in order to recognize possible issues and correct them …
gene sets is of critical importance in order to recognize possible issues and correct them …
GTDB: an ongoing census of bacterial and archaeal diversity through a phylogenetically consistent, rank normalized and complete genome-based taxonomy
Abstract The Genome Taxonomy Database (GTDB; https://gtdb. ecogenomic. org) provides a
phylogenetically consistent and rank normalized genome-based taxonomy for prokaryotic …
phylogenetically consistent and rank normalized genome-based taxonomy for prokaryotic …
iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
through metagenomics. While metagenomes enable high-throughput exploration of the viral …