Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying
tissue, harbors one of the largest lymphocyte populations in the body, intestinal …

Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive
the development of diverse immune-mediated diseases,,–. However, the key factors that …

Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

Intestinal intraepithelial lymphocytes (IELs) are a large and diverse population of lymphoid
cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …

Intestinal intraepithelial lymphocytes (IELs) are located at the critical interface between the
intestinal lumen, which is chronically exposed to food and microbes, and the core of the …

The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet,
enteroendocrine, and tuft cells as well as other cell populations, all of which contribute …

The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …