The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes often upregulated
in cancer cells and associated with therapeutic resistance. In humans, the ALDH family …

Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid
(FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently …

Ferroptosis is a recently described programmed cell death mechanism that is characterized
by the buildup of iron (Fe)-dependent lipid peroxides in cells and is morphologically …

Disulfiram (DSF) is an anti-alcoholism medication with superior antitumor activity and clinical
safety; its antitumor mechanisms in gastric cancer (GC) have not been fully explored. In the …

Sorafenib is a potent inducer of ferroptosis used to manage hepatocellular carcinoma
(HCC). The ferroptosis induced by sorafenib activates the p62–Keap1–Nrf2 pathway …

Ferroptosis holds great potential in cancer treatment, but its efficacy is severely limited by a
low Fenton reaction efficacy. Meanwhile, the interactive relationship between Ferroptosis …

Purpose Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation.
Intriguingly, KRAS-mutant cancers are particularly vulnerable to ferroptosis. Osthole is a …

Background The failure of proper recognition of the intricate nature of pathophysiology in
colorectal cancer (CRC) has a substantial effect on the progress of develo** novel …

Cadmium, a toxic heavy metal from industrial activities, poses a neurotoxic risk, especially to
children. While seizures are common in children, the link between cadmium and seizure …