CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease

J Lantero-Rodriguez, L Montoliu-Gaya… - Acta …, 2024 - Springer
Post-mortem staging of Alzheimer's disease (AD) neurofibrillary pathology is commonly
performed by immunohistochemistry using AT8 antibody for phosphorylated tau (p-tau) at …

[HTML][HTML] Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology

J Therriault, NJ Ashton, I Pola, G Triana-Baltzer… - …, 2024 - thelancet.com
Background Blood-based biomarkers of Alzheimer's disease (AD) have become
increasingly important as scalable tools for diagnosis and determining clinical trial eligibility …

Comparison of immunoassay-with mass spectrometry-derived p-tau quantification for the detection of Alzheimer's disease pathology

J Therriault, MS Woo, G Salvadó, J Gobom… - Molecular …, 2024 - Springer
Background Antibody-based immunoassays have enabled quantification of very low
concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF) …

HSV-1 infection induces phosphorylated tau propagation among neurons via extracellular vesicles

V Protto, MT Miteva, F Iannuzzi, ME Marcocci… - Mbio, 2024 - journals.asm.org
Extracellular vesicles (EV), key players in cell-to-cell communication, may contribute to
disease propagation in several neurodegenerative diseases, including Alzheimer's disease …

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease

Z Hoglund, N Ruiz-Uribe, E Del Sastre, B Woost… - Acta …, 2024 - Springer
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral
amyloid angiopathy (CAA), exerting a toxic effect on vascular cells and impacting cerebral …

The Relationship between p-tau217, p-tau231, and p-tau205 in the human brain is affected by the cellular environment and Alzheimer's Disease pathology

M Wennström, N Schultz, PM Gallardo… - Cells, 2024 - mdpi.com
The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early
amyloid beta (Aß) changes in the brain, while the CSF levels of p-tau205 are foremost …

Guidelines for the use and interpretation of Alzheimer's disease biomarkers in clinical practice in Brazil: recommendations from the Scientific Department of Cognitive …

A Studart, BJAP Barbosa, AM Coutinho… - Dementia & …, 2024 - SciELO Brasil
In recent years, the diagnostic accuracy of Alzheimer's disease has been enhanced by the
development of different types of biomarkers that indicate the presence of neuropathological …

Auditory cognition in Alzheimer's Disease

M Lad - 2023 - theses.ncl.ac.uk
Mounting evidence suggests a significant association between hearing loss and an elevated
risk of dementia, yet its neurobiological underpinnings remain largely unknown. A decline in …

[HTML][HTML] Fluid biomarkers unveil signatures of pathological aging

N Hansen, J Wiltfang - Seizure: European Journal of Epilepsy, 2024 - Elsevier
Aging is a multifaceted and highly varied process in the brain. Identifying aging biomarkers
is one means of distinguishing pathological from physiological aging. The aim of this …