Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
Macrophages in lung injury, repair, and fibrosis
P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation
Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis
L Yang, J Fu, X Han, C Zhang, L **a, R Zhu… - Journal of Allergy and …, 2022 - Elsevier
Background Circular RNA (circRNA) has been implicated in various diseases; however, its
role in atopic dermatitis (AD) or psoriasis remains unclear. Objective We sought to determine …
role in atopic dermatitis (AD) or psoriasis remains unclear. Objective We sought to determine …
ATF3-activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in …
Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …
Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques
Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are
pivotal mediators of the immune response, yet little is known about their properties at the …
pivotal mediators of the immune response, yet little is known about their properties at the …
The role of macrophages polarization in sepsis-induced acute lung injury
Z Wang, Z Wang - Frontiers in immunology, 2023 - frontiersin.org
Sepsis presents as a severe infectious disease frequently documented in clinical settings.
Characterized by its systemic inflammatory response syndrome, sepsis has the potential to …
Characterized by its systemic inflammatory response syndrome, sepsis has the potential to …
The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis
B Shu, YX Zhou, H Li, RZ Zhang, C He, X Yang - Cell death discovery, 2021 - nature.com
Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver
fibrosis. In this study, we examined the mechanism and the significance of a signaling axis …
fibrosis. In this study, we examined the mechanism and the significance of a signaling axis …
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis
Hyperactive and damaging inflammation is a hallmark of severe rather than mild
Coronavirus disease 2019 (COVID-19). To uncover key inflammatory differentiators between …
Coronavirus disease 2019 (COVID-19). To uncover key inflammatory differentiators between …