Advancing cancer research and medicine with single-cell genomics
Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
Single-cell multiomics: multiple measurements from single cells
Single-cell sequencing provides information that is not confounded by genotypic or
phenotypic heterogeneity of bulk samples. Sequencing of one molecular type (RNA …
phenotypic heterogeneity of bulk samples. Sequencing of one molecular type (RNA …
[HTML][HTML] Ordered and deterministic cancer genome evolution after p53 loss
Although p53 inactivation promotes genomic instability and presents a route to malignancy
for more than half of all human cancers,, the patterns through which heterogenous TP53 …
for more than half of all human cancers,, the patterns through which heterogenous TP53 …
Somatic genomic changes in single Alzheimer's disease neurons
Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …
specific events that cause neuronal dysfunction and death remain poorly understood. During …
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …
remains challenging to distinguish normal cell types in the tumor microenvironment from …
Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing
Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
Toward minimal residual disease-directed therapy in melanoma
Many patients with advanced cancers achieve dramatic responses to a panoply of
therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse …
therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse …
Breast tumours maintain a reservoir of subclonal diversity during expansion
Our knowledge of copy number evolution during the expansion of primary breast tumours is
limited,. Here, to investigate this process, we developed a single-cell, single-molecule DNA …
limited,. Here, to investigate this process, we developed a single-cell, single-molecule DNA …
Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy
The biological and functional heterogeneity between tumors—both across and within cancer
types—poses a challenge for immunotherapy. To understand the factors underlying tumor …
types—poses a challenge for immunotherapy. To understand the factors underlying tumor …