Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

Single-molecule localization microscopy (SMLM) leverages the power of modern optics to
unleash ultra-precise structural nanoscopy of complex biological machines in their native …

With the widespread uptake of two-dimensional (2D) and three-dimensional (3D) single-
molecule localization microscopy (SMLM), a large set of different data analysis packages …

Peer-reviewed journal publication is the main means for academic researchers in the life
sciences to create a permanent public record of their work. These publications are also the …

There is a need for sensing technologies that can continuously monitor concentration levels
of critical biomolecules in applications such as patient care, fundamental biological …

Cortisol is a steroid hormone involved in a wide range of medical conditions. The level of the
hormone fluctuates over time, but with traditional laboratory-based assays, such dynamics …

The bacterial SOS response represents a paradigm of gene networks controlled by a master
transcriptional regulator. Self-cleavage of the SOS repressor LexA induces a wide range of …

Super-resolution microscopy has profoundly transformed how we study the architecture of
cells, revealing unknown structures and refining our view of cellular assemblies. Among the …

Defining the cellular factors that drive growth rate and proteome composition is essential for
understanding and manipulating cellular systems. In bacteria, ribosome concentration is …

Spatially controlled, cargo-specific endocytosis is essential for development, tissue
homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the …