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The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival
Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …
[HTML][HTML] The molecular basis of mammary gland development and epithelial differentiation
Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …
organ systems has been increasing rapidly in recent years. With the advent of new and …
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
S Pece, D Tosoni, S Confalonieri, G Mazzarol… - Cell, 2010 - cell.com
Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report
the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured …
the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured …
aPKC cycles between functionally distinct PAR protein assemblies to drive cell polarity
The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase
C (aPKC) form a core unit of the PAR protein network, which plays a central role in …
C (aPKC) form a core unit of the PAR protein network, which plays a central role in …
Epithelial organization, cell polarity and tumorigenesis
Epithelial cells comprise the foundation for the majority of organs in the mammalian body,
and are the source of approximately 90% of all human cancers. Characteristically, epithelial …
and are the source of approximately 90% of all human cancers. Characteristically, epithelial …
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis
Loss of epithelial organization is a hallmark of carcinomas, but whether polarity regulates
tumor growth and metastasis is poorly understood. To address this issue, we depleted the …
tumor growth and metastasis is poorly understood. To address this issue, we depleted the …
The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity
PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …
Rewiring cell polarity signaling in cancer
Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …
polarity complexes function to specify and maintain apical and basolateral membrane …
Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
Cell rearrangements shape the Drosophila embryo via spatially regulated changes in cell
shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized …
shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized …
Asymmetric cell division of stem and progenitor cells during homeostasis and cancer
Stem and progenitor cells are characterized by their ability to self-renew and produce
differentiated progeny. A fine balance between these processes is achieved through …
differentiated progeny. A fine balance between these processes is achieved through …