A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …

Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …

The immune system can identify and destroy nascent tumor cells in a process termed cancer
immunosurveillance, which functions as an important defense against cancer. Recently …

Human papillomavirus (HPV) infection drives tumorigenesis in the majority of cervical,
oropharyngeal, anal, and vulvar cancers. Genetic and epidemiologic evidence has …

The presence of inflammatory immune cells in human tumors raises a fundamental question
in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor …

Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

Several infectious agents are considered to be causes of cancer in humans. The fraction of
the different types of cancer, and of all cancers worldwide and in different regions, has been …

Background Effective antiretroviral therapy has reduced the risk of AIDS and dramatically
prolonged the survival of HIV-infected people in the United States. Consequently, an …