Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional chemical
modifications. Approximately 100 different modifications have been identified in tRNAs, and …

Abstract The RNA polymerase III (Pol III) transcriptome is universally comprised of short,
highly structured noncoding RNA (ncRNA). Through RNA–protein interactions, the Pol III …

The advancement of genetic code expansion (GCE) technology is attributed to the
establishment of specific aminoacyl-tRNA synthetase/tRNA pairs. While earlier …

In the past decade tRNA sequencing (tRNA-seq) has attracted considerable attention as an
important tool for the development of novel approaches to quantify highly modified tRNA …

The discovery of reversible modifications in messenger RNA (mRNA) opens new research
directions in RNA modification-mediated epigenetic regulation. Yeast is an extensively used …

Nucleic acid sensors survey subcellular compartments for atypical or mislocalized RNA or
DNA, ultimately triggering innate immune responses. Retinoic acid-inducible gene-I (RIG-I) …

Microplastics have evolutionary and ecological impacts across species, affecting organisms'
development, reproduction, and behavior along with contributing to genotoxicity and stress …

Defects in tRNA biogenesis are associated with multiple neurological disorders, yet our
understanding of these diseases has been hampered by an inability to determine tRNA …

Dihydrouridine (D) is a common modified base found predominantly in transfer RNA (tRNA).
Despite its prevalence, the mechanisms underlying dihydrouridine biosynthesis, particularly …