Harnessing the power of Raman spectroscopic imaging for ophthalmology

J Li, P Yan, Y Li, M Han, Q Zeng, J Li, Z Yu… - Frontiers in …, 2023 - frontiersin.org
Eye diseases can cause great inconvenience to people's daily life; therefore, it is necessary
to study the causes of ocular diseases and related physiological processes. Raman …

Multiomics analysis reveals novel genetic determinants for lens differentiation, structure, and transparency

J Disatham, L Brennan, A Cvekl, M Kantorow - Biomolecules, 2023 - mdpi.com
Recent advances in next-generation sequencing and data analysis have provided new
gateways for identification of novel genome-wide genetic determinants governing tissue …

Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues

B Thompson, EA Davidson, Y Chen, DJ Orlicky… - Chemico-biological …, 2022 - Elsevier
Recent reports have challenged the notion that the lens is immune-privileged. However,
these studies have not fully identified the molecular mechanism (s) that promote immune …

A possible connection between reactive oxygen species and the unfolded protein response in lens development: From insight to foresight

L Gao, N **, Z Ye, T Ma, Y Huang, H Li… - Frontiers in Cell and …, 2022 - frontiersin.org
The lens is a relatively special and simple organ. It has become an ideal model to study the
common developmental characteristics among different organic systems. Lens development …

Cataractogenesis and molecular pathways, with reactive free oxygen species as a common pathway

AIP Pacheco - Survey of Ophthalmology, 2024 - Elsevier
Slowing down or stop** the natural process of cataractogenesis is certainly a challenge
for those who today propose an option other than surgery. Addressing the same problem in …

Glutathione safeguards TET‐dependent DNA demethylation and is critical for the acquisition of totipotency and pluripotency during preimplantation development

J Liu, M Chu, J Zhang, J He, Q Yang, L Tao… - The FASEB …, 2024 - Wiley Online Library
During early development, both genome‐wide epigenetic reprogramming and metabolic
remodeling are hallmark changes of normal embryogenesis. However, little is known about …

TDDFT study on the simultaneous sensing mechanism for peroxynitrite and glutathione by a bifunctional fluorescent probe

W Si-Jia, L Peng-Yuan, Z Hang, S Lei, L Dong… - … Acta Part A: Molecular …, 2023 - Elsevier
Using time-dependent density functional theory (TDDFT) method, the response mechanism
of a reported bifunctional fluorescent probe for simultaneous recognition of peroxynitrite and …

[HTML][HTML] The development and the genetic diseases of the ciliary body

B Li, T **e, S Nawy, Y Shen - Cell Insight, 2024 - Elsevier
The ciliary body, located at the junction of the choroid and iris, is crucial in the development
of the embryonic eye. Notch2 signalling, Wnt signalling, transforming growth factor β (TGF-β) …

Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype

EA Davidson, Y Chen, S Singh, DJ Orlicky… - bioRxiv, 2023 - biorxiv.org
Reduced glutathione (GSH) is an abundant antioxidant that regulates intracellular redox
homeostasis by scavenging reactive oxygen species (ROS). Glutamate-cysteine ligase …

Anp32b Deficiency Suppresses Ocular Development by Repression of Pax6

YS Wei, HR Liu, Q Yang, Z Zhi, Y Yu - Ophthalmic Research, 2024 - karger.com
Introduction: This study aimed to elucidate the role and molecular mechanisms of acidic
leucine-rich nuclear phosphoprotein 32 kDa B (Anp32b) deficiency in ocular development …