In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on map** integration sites in libraries of random transposon mutants to …

INTRODUCTION Nearly all mycobacterial species are free-living environmental
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …

Immuno-oncology has revolutionized cancer treatment and has opened up new
opportunities for develo** vaccination methods. DNA-based cancer vaccines have …

Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …

Highlights•Bacterial genomes contain C 5-methyl-cytosine, N 4-methyl-cytosine, and N 6-
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …

Molecular ty** has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …