Pathogenic role of mitogen activated protein kinases in protozoan parasites

P Kaur, N Goyal - Biochimie, 2022 - Elsevier
Protozoan parasites with complex life cycles have high mortality rates affecting billions of
human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity …

Piplartine-inspired 3, 4, 5-trimethoxycinnamates: Trypanocidal, mechanism of action, and in silico evaluation

CSMB Filho, RR de Menezes, EP Magalhães… - Molecules, 2023 - mdpi.com
Chagas disease (CD) is one of the main neglected tropical diseases that promote relevant
socioeconomic impacts in several countries. The therapeutic options for the treatment of CD …

Identification of functional MKK3/6 and MEK1/2 homologs from Echinococcus granulosus and investigation of protoscolecidal activity of mitogen-activated protein …

C Zhang, J Li, T Aji, L Li, X Bi, N Yang, Z Li… - Antimicrobial Agents …, 2019 - journals.asm.org
Cystic echinococcosis is a zoonosis caused by the larval stage of Echinococcus granulosus
sensu lato. There is an urgent need to develop new drugs for the treatment of this disease. In …

Molecular mechanism by which Apis cerana cerana MKK6 (AccMKK6)-mediated MAPK cascades regulate the oxidative stress response

X Wang, C Wang, X Cui, L Wang, Z Liu… - Bioscience …, 2018 - portlandpress.com
Mitogen-activated protein kinase kinases (MKKs) are important components of the MAPK
signaling pathways, which play a key role in responding to stress and inflammatory stimuli …

Genome-Wide Proteomics and Phosphoproteomics Analysis of Trypanosoma cruzi During Differentiation

M Batista, JC Amorim, ACR Lucena… - … : Methods and Protocols, 2020 - Springer
Trypanosoma cruzi is a pathogenic protozoan that still has an impact on public health,
despite the decrease in the number of infection cases along the years. T. cruzi possesses an …