Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on
survival. A lack of consistency in outcome reporting between trials limits the opportunities to …

Objective: To update, clarify, and extend IDEAL concepts and recommendations.
Background: New surgical procedures, devices, and other complex interventions need …

Background Participants in clinical research studies often do not reflect the populations for
which healthcare interventions are needed or will be used. Enhancing representation of …

Clinical trial consent for protocols and their revisions should be transparent for patients and
traceable for stakeholders. Our goal is to implement a process allowing for collection of …

Randomised trials are a central component of all evidence-informed health care systems
and the evidence coming from them helps to support health care users, health professionals …

Plain Language Summary Funders of research are increasingly requiring researchers to
involve patients and the public in their research. Patient and public involvement (PPI) in …

Objective To collect and classify reported reasons for recruitment failure in discontinued
randomized controlled trials (RCTs) and to assess reporting quality. Methods We …

Fewer than half of new drugs have data on their comparative benefits and harms against
existing treatment options at the time of regulatory approval in Europe and the USA. Even …

Background More than a third of the 65,000 people living with kidney failure in the UK attend
a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 h. In haemodialysis …