Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in
medicinal chemistry. Allosteric modulators, ie, compounds which bind in a receptor site …

Recent years have seen the rise of allosteric modulation as an innovative approach for drug
design and discovery, efforts which culminated in the development of several clinical …

This work describes the synthesis and pharmacological and toxicological evaluation of
melanostatin (MIF-1) bioconjugates with amantadine (Am) via a peptide linkage. The data …

This work describes the synthesis and pharmacological evaluation of 2-furoyl-based
Melanostatin (MIF-1) peptidomimetics as dopamine D2 modulating agents. Eight novel …

The control of Parkinson's disease (PD) is challenged by the motor and non-motor
fluctuations as well as dyskinesias associated with levodopa long-term therapy. As such …

Neurodegenerative disorders of the central nervous system are a class of heterogeneous
pathologies affecting millions of people worldwide and represent a global health burden in …

A convenient synthetic protocol for the unprecedented N-hydroxylation of proline residue in
Melanostatin (MIF-1) neuropeptide is reported. This methodology is grounded on the …

The present thesis manuscript concludes my semi-industrial PhD fellowship in both the
fields of peptide synthesis in the Research Group of Organic Chemistry (ORGC), Faculty of …

A mitocôndria desempenha um papel vital na regulação do metabolismo de energia celular.
A sua capacidade de regular o equilíbrio redox é fundamental no controlo da vida e da …