In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …

Fluorescent calcium indicators are a popular means for observing the spiking activity of
large neuronal populations, but extracting the activity of each neuron from raw fluorescence …

In this review, we discuss the emerging field of computational behavioral analysis—the use
of modern methods from computer science and engineering to quantitatively measure …

While motor cortical circuits contain information related to specific movement parameters,
long-range inputs also have a critical role in action execution,. Thalamic projections can …

Identifying low-dimensional features that describe large-scale neural recordings is a major
challenge in neuroscience. Repeated temporal patterns (sequences) are thought to be a …

Objective. Fluorescence imaging through head-mounted microscopes in freely behaving
animals is becoming a standard method to study neural circuit function. Flexible, open …

How are actions linked with subsequent outcomes to guide choices? The nucleus
accumbens, which is implicated in this process, receives glutamatergic inputs from the …

Neuronal ensembles, defined as groups of neurons displaying recurring patterns of
coordinated activity, represent an intermediate functional level between individual neurons …