As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Pancreatic ductal adenocarcinoma (PDAC) is poorly responsive to therapies and
histologically contains a paucity of neoplastic cells embedded within a dense desmoplastic …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Background & Aims We have shown that reciprocally activated rat sarcoma (RAS)/mitogen-
activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus …

We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded
microenvironments, chemoresistance, and poor survival in pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that typically features a
dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated …

Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …