Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …

Recent advances in medical technology and health care have greatly improved the
management for chronic diseases and prolonged human lifespan. Unfortunately, increased …

The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

The expansion of the white adipose tissue (WAT) in obesity goes along with increased
mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still …