Systemic therapy of brain metastases: non–small cell lung cancer, breast cancer, and melanoma
Brain metastases (BM) occur frequently in many cancers, particularly non–small cell lung
cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with …
cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with …
Existing and emerging technologies for tumor genomic profiling
LE MacConaill - Journal of Clinical Oncology, 2013 - ascopubs.org
Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer
genomics and tumor biology. In parallel, information gleaned from these studies on driver …
genomics and tumor biology. In parallel, information gleaned from these studies on driver …
Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin
FS Hodi, CL Corless, A Giobbie-Hurder… - Journal of clinical …, 2013 - ascopubs.org
Purpose Amplifications and mutations in the KIT proto-oncogene in subsets of melanomas
provide therapeutic opportunities. Patients and Methods We conducted a multicenter phase …
provide therapeutic opportunities. Patients and Methods We conducted a multicenter phase …
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
Abstract Knowledge of “actionable” somatic genomic alterations present in each tumor (eg,
point mutations, small insertions/deletions, and copy-number alterations that direct …
point mutations, small insertions/deletions, and copy-number alterations that direct …
Personalized oncology through integrative high-throughput sequencing: a pilot study
Individual cancers harbor a set of genetic aberrations that can be informative for identifying
rational therapies currently available or in clinical trials. We implemented a pilot study to …
rational therapies currently available or in clinical trials. We implemented a pilot study to …
Prevalence of class I–III BRAF mutations among 114,662 cancer patients in a large genomic database
BRAF mutations are relatively common in many cancers, particularly melanoma, colorectal
cancer, and thyroid cancer and to a lesser extent in lung cancer. These mutations can be …
cancer, and thyroid cancer and to a lesser extent in lung cancer. These mutations can be …
BRAF L597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors
KB Dahlman, J **
C Beadling, TL Neff, MC Heinrich, K Rhodes… - The Journal of Molecular …, 2013 - Elsevier
There is growing demand for routine identification of actionable mutations in clinical cancer
specimens. Genoty** platforms must provide rapid turnaround times and work effectively …
specimens. Genoty** platforms must provide rapid turnaround times and work effectively …