Application of artificial intelligence technology in oncology: Towards the establishment of precision medicine

R Hamamoto, K Suvarna, M Yamada, K Kobayashi… - Cancers, 2020 - mdpi.com
Simple Summary Artificial intelligence (AI) technology has been advancing rapidly in recent
years and is being implemented in society. The medical field is no exception, and the clinical …

N6-Methyladenosine RNA modification in the tumor immune microenvironment: novel implications for immunotherapy

L Guo, H Yang, C Zhou, Y Shi, L Huang… - Frontiers in …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation is one of the most common modifications of RNA in
eukaryotic cells, and is mainly regulated by m6A methyltransferases (writers), m6A …

Integrated analysis of whole genome and epigenome data using machine learning technology: toward the establishment of precision oncology

K Asada, S Kaneko, K Takasawa, H Machino… - Frontiers in …, 2021 - frontiersin.org
With the completion of the International Human Genome Project, we have entered what is
known as the post-genome era, and efforts to apply genomic information to medicine have …

Regulation of m6A methylation as a new therapeutic option against COVID-19

C Zannella, L Rinaldi, G Boccia, A Chianese… - Pharmaceuticals, 2021 - mdpi.com
The rapid spread of SARS-CoV-2 and the resulting pandemic has led to a spasmodic search
for approaches able to limit the diffusion of the disease. The epigenetic machinery has …

A Light‐Controllable Chemical Modulation of m6A RNA Methylation

L Lan, YJ Sun, XY **, LJ **e, L Liu… - Angewandte …, 2021 - Wiley Online Library
Bioactive small molecules with photo‐removable protecting groups have provided spatial
and temporal control of corresponding biological effects. We present the design, synthesis …

Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules

A Bolatkan, K Asada, S Kaneko… - International …, 2021 - spandidos-publications.com
RNA modifications have attracted increasing interest in recent years because they have
been frequently implicated in various human diseases, including cancer, highlighting the …

[HTML][HTML] On the specificity of the recognition of m6A-RNA by YTH reader domains

J Widmer, A Vitalis, A Caflisch - Journal of Biological Chemistry, 2024 - Elsevier
Most processes of life are the result of polyvalent interactions between macromolecules,
often of heterogeneous types and sizes. Frequently, the times associated with these …

RNA m6A methylation regulators in liver cancer

Q Xu, N Ren, L Ren, Y Yang, J Pan, H Shang - Cancer Cell International, 2024 - Springer
Liver cancer is one of the most common cancers in the world and a primary cause of cancer-
related death. In recent years, despite the great development of diagnostic methods and …

[HTML][HTML] METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5

Y Tang, G Gao, W **a, J Wang - Cellular signalling, 2022 - Elsevier
Background Pancreatic cancer belongs to lethal cancer with limited efficient treatment
currently, and its main cause of death is rapid tumor growth and early metastasis. N6 …

Pseudorabies virus exploits N6-methyladenosine modification to promote viral replication

PL Yu, R Wu, SJ Cao, YP Wen, XB Huang… - Frontiers in …, 2023 - frontiersin.org
Introduction Pseudorabies virus (PRV) is the pathogenic virus of porcine pseudorabies (PR),
belonging to the Herpesviridae family. PRV has a wide range of hosts and in recent years …