Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic …

S Zhang, HF Yao, H Li, T Su, SH Jiang, H Wang… - Cellular Oncology, 2023 - Springer
Abstract Purpose Transglutaminases (TGs) are multifunctional enzymes exhibiting
transglutaminase crosslinking, as well as atypical GTPase/ATPase and kinase activities …

The biological functions and pathological mechanisms of CASK in various diseases

X Liu, H Qin, Y Liu, J Ma, Y Li, Y He, H Zhu, L Mao - Heliyon, 2024 - cell.com
Background As a scaffold protein, calcium/calmodulin-dependent serine protein kinase
(CASK) has been extensively studied in a variety of tissues throughout the body. The Cask …

Discovering breast cancer biomarkers candidates through mRNA expression analysis based on the cancer genome atlas database

DH Kim, KE Lee - Journal of Personalized Medicine, 2022 - mdpi.com
Background: Research on the discovery of tumor biomarkers based on big data analysis is
actively being conducted. This study aimed to secure foundational data for identifying new …

Long noncoding RNA AATBC promotes the proliferation and migration of prostate cancer cell through miR-1245b-5p/CASK axis

W Zhang, Q Liu, J Zhao, T Wang… - Cancer management and …, 2021 - Taylor & Francis
Introduction Long noncoding RNAs (lncRANs) as suppressive or oncogenic genes have
been substantiated in prostate cancer (PCa). In the current study, the role and molecular …

CASK regulates Notch pathway and functions as a tumor promoter in pancreatic cancer

J Qu, Y Zhou, Y Li, J Yu, W Wang - Archives of Biochemistry and Biophysics, 2021 - Elsevier
Calcium/calmodulin-dependent serine protein kinase (CASK), a member of membrane-
associated guanylate kinase (MAGUK) super-family, is implicated in regulating cell …

Transmembrane and Ubiquitin‐Like Domain‐Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis

Y Liu, C Cai, K Wu, L Hu - International Journal of Genomics, 2023 - Wiley Online Library
Background. Ubiquitin‐related proteins have garnered increasing attention for their roles in
tumorigenesis. Transmembrane and ubiquitin‐like domain‐containing 1 (TMUB1) is a …

Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer

LF Dagley, J Yousef, A Preaudet, A Loving… - International Journal of …, 2024 - mdpi.com
There are a limited number of clinically useful serum biomarkers to predict tumor onset or
treatment response in gastric cancer (GC). For this reason, we explored the serum proteome …

Combined metabolomic and proteomic analysis of sepsis related acute liver injury and its pathogenesis research

J Zhang, X Wang, Y Peng, J Wei, Y Luo, F Luan… - International …, 2024 - Elsevier
Background Sepsis-induced acute liver injury is common in patients in intensive care units.
However, the exact mechanism of this condition remains unclear. The purpose of this study …

The effect of hsa-miR-451b knockdown on biological functions of gastric cancer stem-like cells

DB Farahani, H Akrami, B Moradi, K Mehdizadeh… - Biochemical …, 2021 - Springer
Numerous researches have extensively studied factors such as microRNAs that lead to
cancer. Thus, the current study's purpose is to investigate the biological consequences of …

[HTML][HTML] Identification of differentially expressed genes associated with coronary in-stent restenosis by integrated bioinformatics approaches

M Chen, Y Dun, W Zhang, S Liu - Annals of Palliative Medicine, 2022 - apm.amegroups.org
Background: In-stent restenosis (ISR) is a common complication following percutaneous
coronary intervention (PCI). Designing ISR-specific therapeutic targets is important for …