Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for
their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO …

In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents
the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in
over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors …

Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly
use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi …

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have
been proved to be of vital importance to elucidate the mechanisms of platelet thrombus …

The vascular system is one of the first to develop during embryogenesis and is essential for
all organs and tissues in our body to develop and function. It has many essential roles …

Intravascular administration of plasminogen activators is a clinically important thrombolytic
strategy to treat occlusive vascular conditions. A major issue with this strategy is the systemic …

Chemokines orchestrate leukocyte trafficking and function in health and disease.
Heterophilic interactions between chemokines in a given microenvironment may amplify …