Zebrafish as tools for drug discovery

CA MacRae, RT Peterson - Nature reviews Drug discovery, 2015 - nature.com
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

[HTML][HTML] The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

W Zhao, Y Chen, N Hu, D Long, Y Cao - Ecotoxicology and Environmental …, 2024 - Elsevier
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish
(Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about …

Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS

S Gaballah, A Swank, JR Sobus… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial
chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is …

Zebrafish in toxicology and environmental health

K Bambino, J Chu - Current topics in developmental biology, 2017 - Elsevier
As manufacturing processes and development of new synthetic compounds increase to
keep pace with the expanding global demand, environmental health, and the effects of …

Making waves: New developments in toxicology with the zebrafish

KA Horzmann, JL Freeman - Toxicological Sciences, 2018 - academic.oup.com
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …

From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational …

Y Wang, P Wang, T Fan, T Ren, N Zhang… - Journal of Hazardous …, 2024 - Elsevier
The escalating introduction of pesticides/veterinary drugs into the environment has
necessitated a rapid evaluation of their potential risks to ecosystems and human health. The …

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

K Paul Friedman, M Gagne, LH Loo… - Toxicological …, 2020 - academic.oup.com
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …

Improving the human hazard characterization of chemicals: a Tox21 update

RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

C Chakraborty, AR Sharma, G Sharma… - Journal of …, 2016 - Springer
Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range
of industries, such as medicine, electronics and chemistry. In the current era, the commercial …

Zebrafish: an important tool for liver disease research

W Goessling, KC Sadler - Gastroenterology, 2015 - Elsevier
As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …