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Zebrafish as tools for drug discovery
CA MacRae, RT Peterson - Nature reviews Drug discovery, 2015 - nature.com
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …
contributed to several examples of successful phenotype-based drug discovery. For the …
[HTML][HTML] The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics
W Zhao, Y Chen, N Hu, D Long, Y Cao - Ecotoxicology and Environmental …, 2024 - Elsevier
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish
(Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about …
(Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about …
Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS
S Gaballah, A Swank, JR Sobus… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial
chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is …
chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is …
Zebrafish in toxicology and environmental health
K Bambino, J Chu - Current topics in developmental biology, 2017 - Elsevier
As manufacturing processes and development of new synthetic compounds increase to
keep pace with the expanding global demand, environmental health, and the effects of …
keep pace with the expanding global demand, environmental health, and the effects of …
Making waves: New developments in toxicology with the zebrafish
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational …
Y Wang, P Wang, T Fan, T Ren, N Zhang… - Journal of Hazardous …, 2024 - Elsevier
The escalating introduction of pesticides/veterinary drugs into the environment has
necessitated a rapid evaluation of their potential risks to ecosystems and human health. The …
necessitated a rapid evaluation of their potential risks to ecosystems and human health. The …
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …
potential to accelerate the pace of human health safety evaluation by informing screening …
Improving the human hazard characterization of chemicals: a Tox21 update
RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …
Toxicology Program, the US Environmental Protection Agency's National Center for …
Zebrafish: A complete animal model to enumerate the nanoparticle toxicity
Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range
of industries, such as medicine, electronics and chemistry. In the current era, the commercial …
of industries, such as medicine, electronics and chemistry. In the current era, the commercial …
Zebrafish: an important tool for liver disease research
As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …