GABA tone regulation and its cognitive functions in the brain

W Koh, H Kwak, E Cheong, CJ Lee - Nature Reviews Neuroscience, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …

Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekee** and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

Roles of neuropeptides, VIP and AVP, in the mammalian central circadian clock

D Ono, K Honma, S Honma - Frontiers in neuroscience, 2021 - frontiersin.org
In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of
the hypothalamus. Individual SCN cells exhibit intrinsic oscillations, and their circadian …

The suprachiasmatic nucleus at 50: looking back, then looking forward

D Ono, DR Weaver, MH Hastings… - Journal of biological …, 2024 - journals.sagepub.com
It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

Astrocytic control of extracellular GABA drives circadian timekee** in the suprachiasmatic nucleus

AP Patton, EL Morris, D McManus, H Wang, Y Li… - Proceedings of the …, 2023 - pnas.org
The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock.
Its cell-autonomous timing mechanism, a transcriptional/translational feedback loop (TTFL) …

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus

D Ono, Y Mukai, CJ Hung, S Chowdhury… - Science …, 2020 - science.org
In mammals, the daily rhythms of physiological functions are timed by the central circadian
clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Although the …

Disturbances of hormonal circadian rhythms by light pollution

M Zeman, M Okuliarova, VS Rumanova - International Journal of …, 2023 - mdpi.com
The circadian rhythms evolved to anticipate and cope with cyclic changes in environmental
conditions. This adaptive function is currently compromised by increasing levels of artificial …

NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior

P Xu, S Berto, A Kulkarni, B Jeong, C Joseph, KH Cox… - Neuron, 2021 - cell.com
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker in mammals and is
entrained by environmental light. However, the molecular basis of the response of the SCN …

GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior

T Maejima, Y Tsuno, S Miyazaki, Y Tsuneoka… - Proceedings of the …, 2021 - pnas.org
The suprachiasmatic nucleus (SCN), the central circadian pacemaker in mammals, is a
network structure composed of multiple types of γ-aminobutyric acid (GABA)-ergic neurons …

The concept of coupling in the mammalian circadian clock network

V Pilorz, M Astiz, KO Heinen, O Rawashdeh… - Journal of molecular …, 2020 - Elsevier
The circadian clock network regulates daily rhythms in mammalian physiology and behavior
to optimally adapt the organism to the 24-h day/night cycle. A central pacemaker, the …