In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …

The helix is the central structural motif in biological macromolecules, such as DNA and
proteins, and is also the ubiquitous object in nature from microscopic to macroscopic points …

In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril
formation were studied under different conditions using the fluorescent dye thioflavin T …

Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to
amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In …

Recent reports give strong support to the idea that amyloid fibril formation and the
subsequent development of protein deposition diseases originate from conformational …

Under solution conditions where the native state is destabilized, the largely helical
polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic …

Recent progress has improved our knowledge of how proteins form amyloid fibrils. Both
'natively unfolded'and globular proteins have been shown to initiate fibrillization by adopting …

We report the detailed mechanical characterization of individual amyloid fibrils by atomic
force microscopy and spectroscopy. These self-assembling materials, formed here from the …