Towards clinical translation of FLASH radiotherapy
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
[HTML][HTML] FLASH radiotherapy treatment planning and models for electron beams
M Rahman, A Trigilio, G Franciosini, R Moeckli… - Radiotherapy and …, 2022 - Elsevier
The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Proton FLASH radiation therapy and immune infiltration: evaluation in an orthotopic glioma rat model
L Iturri, A Bertho, C Lamirault, M Juchaux… - International Journal of …, 2023 - Elsevier
Purpose FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses
ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT …
ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT …
VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
HC Wanstall, P Korysko, W Farabolini, R Corsini… - Scientific Reports, 2024 - nature.com
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy
tissue, an effect known as 'FLASH'. This effect has been studied across several radiation …
tissue, an effect known as 'FLASH'. This effect has been studied across several radiation …
Nonlinear pulse compression of a 200 mJ and 1 kW ultrafast thin-disk amplifier
Y Pfaff, G Barbiero, M Rampp, S Klingebiel, J Brons… - Optics express, 2023 - opg.optica.org
We present a high-energy laser source consisting of an ultrafast thin-disk amplifier followed
by a nonlinear compression stage. At a repetition rate of 5 kHz, the drive laser provides a …
by a nonlinear compression stage. At a repetition rate of 5 kHz, the drive laser provides a …
Enhanced laser wakefield acceleration utilizing Hermite–Gaussian laser pulses in homogeneous plasma
The paper investigates the phenomenon of laser wakefield acceleration in a collisionless
underdense plasma using Hermite–Gaussian laser pulses. Laser wakefield acceleration is a …
underdense plasma using Hermite–Gaussian laser pulses. Laser wakefield acceleration is a …
A 2D strip ionization chamber array with high spatiotemporal resolution for proton pencil beam scanning FLASH radiotherapy
Purpose Experimental measurements of two‐dimensional (2D) dose rate distributions in
proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In …
proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In …
Treatment planning consideration for very high-energy electron FLASH radiotherapy
G Zhang, Z Zhang, W Gao, H Quan - Physica Medica, 2023 - Elsevier
Purpose Very high-energy electron (VHEE) can make up the insufficient treatment depth of
the low-energy electron while offering an intermediate dosimetric advantage between …
the low-energy electron while offering an intermediate dosimetric advantage between …
Very high-energy electrons as radiotherapy opportunity
J Fischer, L Whitmore, C Desrosiers… - … Physical Journal Plus, 2024 - epjplus.epj.org
The use of very high-energy electrons (VHEEs) with energies in the range of 100-250 MeV
has recently garnered significant attention for use in radiotherapy. VHEE beams manifest …
has recently garnered significant attention for use in radiotherapy. VHEE beams manifest …
Impact of multiple beams on the FLASH effect in soft tissue and skin in mice
A Mascia, S McCauley, J Speth, SA Nunez… - International Journal of …, 2024 - Elsevier
Purpose FLASH proton pencil beam scanning (p-PBS) showed a reduction in mouse skin
toxicity and fibrosis when delivered as a single, uninterrupted, high-dose fraction. Clinical p …
toxicity and fibrosis when delivered as a single, uninterrupted, high-dose fraction. Clinical p …