[HTML][HTML] Alzheimer's disease pathophysiology in the retina
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup
Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with
multiple therapeutic avenues to lower amyloid-β burden in Alzheimer's disease (AD). In …
multiple therapeutic avenues to lower amyloid-β burden in Alzheimer's disease (AD). In …
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease
M Calvo-Rodriguez, SS Hou, AC Snyder… - Nature …, 2020 - nature.com
Mitochondria contribute to shape intraneuronal Ca2+ signals. Excessive Ca2+ taken up by
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …
Vasomotion as a driving force for paravascular clearance in the awake mouse brain
Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important
process in brain health and diseases such as Alzheimer's disease (AD) and cerebral …
process in brain health and diseases such as Alzheimer's disease (AD) and cerebral …
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease
Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …
ApoE4 accelerates early seeding of amyloid pathology
Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …
[HTML][HTML] CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal-and synapse-related gene expression in APP-PS1 transgenic mice
MS Unger, E Li, L Scharnagl, R Poupardin… - Brain, Behavior, and …, 2020 - Elsevier
Neuroinflammation is a major contributor to disease progression in Alzheimer's disease
(AD) and is characterized by the activity of brain resident glial cells, in particular microglia …
(AD) and is characterized by the activity of brain resident glial cells, in particular microglia …
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease
Mixed pathology, with both Alzheimer's disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …
common cause of clinical dementia in the elderly. While usually thought to be concurrent …
Exosomes isolated from human umbilical cord mesenchymal stem cells alleviate neuroinflammation and reduce amyloid-beta deposition by modulating microglial …
M Ding, Y Shen, P Wang, Z **e, S Xu, ZY Zhu… - Neurochemical …, 2018 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which has been …
excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which has been …