The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury

R Deng, J Zhou - International Immunopharmacology, 2023 - Elsevier
Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …

[HTML][HTML] Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review

MS Bhuia, P Wilairatana, J Ferdous, R Chowdhury… - Molecules, 2023 - mdpi.com
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to
treat various diseases and ailments. These food items are prominent sources of …

The mechanisms of action of mitochondrial targeting agents in cancer: Inhibiting oxidative phosphorylation and inducing apoptosis

Y Yang, Y An, M Ren, H Wang, J Bai, W Du… - Frontiers in …, 2023 - frontiersin.org
The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …

Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight

M Waseem, BD Wang - International journal of molecular sciences, 2023 - mdpi.com
Cancer has been progressively a major global health concern. With this develo** global
concern, cancer determent is one of the most significant public health challenges of this era …

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

[HTML][HTML] β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian …

H Wang, J Liu, Z Zhang, J Peng, Z Wang, L Yang… - Free Radical Biology …, 2024 - Elsevier
The exploration of drugs derived from natural sources holds significant promise in
addressing current limitations in ovarian cancer (OC) treatments. While previous studies …

ROCK1 promotes migration and invasion of non-small-cell lung cancer cells through the PTEN/PI3K/FAK pathway

C Hu, H Zhou, Y Liu, J Huang… - International …, 2019 - spandidos-publications.com
Rho-associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an
important function in cell migration and invasion in neoplasms. ROCK1 has been found to …

[HTML][HTML] Targeting mitochondrial ion channels for cancer therapy

I Szabo, M Zoratti, L Biasutto - Redox Biology, 2021 - Elsevier
Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

[HTML][HTML] Effective drug concentration and selectivity depends on fraction of primitive cells

JJ Lica, M Wieczór, GJ Grabe, M Heldt, M Jancz… - International journal of …, 2021 - mdpi.com
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has
been driving the search for more active and specific compounds. In this work, we show how …

[HTML][HTML] Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH …

F **aoli, Z Yaqing, L Ruhui, L Xuan, C Aijie… - Journal of hazardous …, 2021 - Elsevier
Graphene oxide (GO) nanomaterials have significant advantages for drug delivery and
electrode materials in neural science, however, their exposure risks to the central nervous …