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The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury
R Deng, J Zhou - International Immunopharmacology, 2023 - Elsevier
Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …
standard intervention. However, reperfusion may lead to further myocardial damage, known …
[HTML][HTML] Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to
treat various diseases and ailments. These food items are prominent sources of …
treat various diseases and ailments. These food items are prominent sources of …
The mechanisms of action of mitochondrial targeting agents in cancer: Inhibiting oxidative phosphorylation and inducing apoptosis
Y Yang, Y An, M Ren, H Wang, J Bai, W Du… - Frontiers in …, 2023 - frontiersin.org
The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …
tumor cells. This process involves changes in metabolic activity, an increase in the amount …
Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight
Cancer has been progressively a major global health concern. With this develo** global
concern, cancer determent is one of the most significant public health challenges of this era …
concern, cancer determent is one of the most significant public health challenges of this era …
Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry
N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …
values by combining with disease targets through various mechanisms. Plant secondary …
[HTML][HTML] β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian …
H Wang, J Liu, Z Zhang, J Peng, Z Wang, L Yang… - Free Radical Biology …, 2024 - Elsevier
The exploration of drugs derived from natural sources holds significant promise in
addressing current limitations in ovarian cancer (OC) treatments. While previous studies …
addressing current limitations in ovarian cancer (OC) treatments. While previous studies …
ROCK1 promotes migration and invasion of non-small-cell lung cancer cells through the PTEN/PI3K/FAK pathway
C Hu, H Zhou, Y Liu, J Huang… - International …, 2019 - spandidos-publications.com
Rho-associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an
important function in cell migration and invasion in neoplasms. ROCK1 has been found to …
important function in cell migration and invasion in neoplasms. ROCK1 has been found to …
[HTML][HTML] Targeting mitochondrial ion channels for cancer therapy
Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …
approach to eliminate cancer cells; as most of these channels are differentially expressed …
[HTML][HTML] Effective drug concentration and selectivity depends on fraction of primitive cells
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has
been driving the search for more active and specific compounds. In this work, we show how …
been driving the search for more active and specific compounds. In this work, we show how …
[HTML][HTML] Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH …
F **aoli, Z Yaqing, L Ruhui, L Xuan, C Aijie… - Journal of hazardous …, 2021 - Elsevier
Graphene oxide (GO) nanomaterials have significant advantages for drug delivery and
electrode materials in neural science, however, their exposure risks to the central nervous …
electrode materials in neural science, however, their exposure risks to the central nervous …