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Emerging connectivity of programmed cell death pathways and its physiological implications
The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
Pattern recognition receptors and the host cell death molecular machinery
GP Amarante-Mendes, S Adjemian, LM Branco… - Frontiers in …, 2018 - frontiersin.org
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …
Programmed cell death as a defence against infection
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they
can die through programmed cell death upon the stimulation of specific signalling pathways …
can die through programmed cell death upon the stimulation of specific signalling pathways …
Necroptosis in development, inflammation and disease
R Weinlich, A Oberst, HM Beere… - Nature reviews Molecular …, 2017 - nature.com
In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …
molecule already recognized as an important regulator of cell survival, inflammation and …
[HTML][HTML] Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity
C Zhou, X Chen, R Planells-Cases, J Chu, L Wang… - Immunity, 2020 - cell.com
The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Necroptosis: mechanisms and relevance to disease
Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …
PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis
The innate immune response provides the first line of defense against infection and disease.
Regulated cell death (RCD) is a key component of innate immune activation, and RCD must …
Regulated cell death (RCD) is a key component of innate immune activation, and RCD must …
Programmed necrosis in inflammation: Toward identification of the effector molecules
BACKGROUND Inflammatory lesions often contain dead cells. Cell death in developmental
processes characteristically occurs by apoptosis, a form of programmed cell death in which …
processes characteristically occurs by apoptosis, a form of programmed cell death in which …