HIV control: Is getting there the same as staying there?
In this brief review and perspective, we address the question of whether the immune
responses that bring about immune control of acute HIV infection are the same as, or distinct …
responses that bring about immune control of acute HIV infection are the same as, or distinct …
Immune responses in controllers of HIV infection
AK Kwaa, JN Blankson - Annual Review of Immunology, 2023 - annualreviews.org
Elite controllers are a heterogeneous group of people living with HIV who control viral
replication without antiretroviral therapy. There is substantial evidence that at least some …
replication without antiretroviral therapy. There is substantial evidence that at least some …
Understanding the evolution of immune genes in jawed vertebrates
Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize
defence against pathogens within a given environment. Recent advances in genetics …
defence against pathogens within a given environment. Recent advances in genetics …
Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
CD4+ T cell–mediated HLA class II cross-restriction in HIV controllers
Rare individuals, termed HIV controllers, spontaneously control HIV infection by mounting
efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV …
efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV …
[HTML][HTML] NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control
N Sánchez-Gaona, A Gallego-Cortés… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Elite controllers (ECs), a unique group of people with HIV (PWH), exhibit remarkable control
of viral replication in the absence of antiretroviral therapy. In this study, we comprehensively …
of viral replication in the absence of antiretroviral therapy. In this study, we comprehensively …
High-resolution human KIR genoty**
J Downing, L D'Orsogna - Immunogenetics, 2022 - Springer
Killer immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through
interactions with various ligands on the surface of cells, thereby determining whether natural …
interactions with various ligands on the surface of cells, thereby determining whether natural …
Host KIR/HLA-c genotypes determine HIV-mediated changes of the NK cell repertoire and are associated with vpu sequence variations impacting downmodulation of …
S Vollmers, A Lobermeyer, A Niehrs, P Fittje… - Frontiers in …, 2022 - frontiersin.org
NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory
receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like …
receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like …
Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural
killer cells, where they play a key role in the regulation of innate immune responses. Recent …
killer cells, where they play a key role in the regulation of innate immune responses. Recent …
The role of KIR positive NK cells in diseases and its importance in clinical intervention
Natural killer (NK) cells are essential for the elimination of the transformed and cancerous
cells. Killer cell immunoglobulin-like receptors (KIRs) which expressed by T and NK cells …
cells. Killer cell immunoglobulin-like receptors (KIRs) which expressed by T and NK cells …