The mechanism of eukaryotic translation initiation and principles of its regulation
Protein synthesis is principally regulated at the initiation stage (rather than during elongation
or termination), allowing rapid, reversible and spatial control of gene expression. Progress …
or termination), allowing rapid, reversible and spatial control of gene expression. Progress …
Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
Comparative protein structure modeling using MODELLER
B Webb, A Sali - Current protocols in bioinformatics, 2016 - Wiley Online Library
Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …
protein sequence (target) based primarily on its alignment to one or more proteins of known …
The structure of the eukaryotic ribosome at 3.0 Å resolution
Ribosomes translate genetic information encoded by messenger RNA into proteins. Many
aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are …
aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are …
[BOOK][B] Three-dimensional electron microscopy of macromolecular assemblies: visualization of biological molecules in their native state
J Frank - 2006 - books.google.com
Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …
biophysics and structural biology at present, and Frank is arguably the most distinguished …
[BOOK][B] Nucleic acids in chemistry and biology
GM Blackburn - 2006 - books.google.com
The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …
are crucial for the understanding of complex biological processes involved. Revised and …
One core, two shells: bacterial and eukaryotic ribosomes
S Melnikov, A Ben-Shem… - Nature structural & …, 2012 - nature.com
Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
We have analyzed the translational status of each mRNA in rapidly growing Saccharomyces
cerevisiae. mRNAs were separated by velocity sedimentation on a sucrose gradient, and 14 …
cerevisiae. mRNAs were separated by velocity sedimentation on a sucrose gradient, and 14 …
[HTML][HTML] The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes
H Haruki, J Nishikawa, UK Laemmli - Molecular cell, 2008 - cell.com
The anchor-away (AA) technique depletes the nucleus of Saccharomyces cerevisiae of a
protein of interest (the target) by conditional tethering to an abundant cytoplasmic protein …
protein of interest (the target) by conditional tethering to an abundant cytoplasmic protein …
The molecular mechanics of eukaryotic translation
LD Kapp, JR Lorsch - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …